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Quantifying bluetongue vertical transmission in French cattle from surveillance data

Author:
Courtejoie, Noémie, Bournez, Laure, Zanella, Gina, Durand, Benoît
Source:
Veterinary research 2019 v.50 no.1 pp. 34
ISSN:
1297-9716
Subject:
Bluetongue virus, bluetongue, heifers, livestock and meat industry, models, monitoring, pregnancy, probability, reverse transcriptase polymerase chain reaction, serotypes, transplacental transmission, vector-borne diseases, virus transmission, France
Abstract:
Bluetongue is a vector-borne disease of ruminants with economic consequences for the livestock industry. Bluetongue virus serotype 8 (BTV-8) caused a massive outbreak in Europe in 2006/2009 and re-emerged in France in 2015. Given the unprecedented epidemiological features of this serotype in cattle, the importance of secondary routes of transmission was reconsidered and transplacental transmission of BTV-8 was demonstrated in naturally and experimentally infected cattle. Here we used surveillance data from the on-going outbreak to quantify BTV-8 vertical transmission in French cattle. We used RT-PCR pre-export tests collected from June to December 2016 on the French territory and developed a catalytic model to disentangle vertical and vector-borne transmission. A series of in silico experiments validated the ability of our framework to quantify vertical transmission provided sufficient prevalence levels. By applying our model to an area selected accordingly, we estimated a probability of vertical transmission of 56% (55.8%, 95% credible interval 41.7–70.6) in unvaccinated heifers infected late in gestation. The influence of this high probability of vertical transmission on BTV-8 spread and persistence should be further investigated.
Agid:
6444597