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Eremophilane sesquiterpenes from the endophytic fungus Xylaria sp. GDG-102

Author:
Liang, Yan, Xu, Weifeng, Liu, Chengmei, Zhou, Dexiong, Liu, Xiaobo, Qin, Yuyue, Cao, Fei, Li, Jun, Yang, Ruiyun, Qin, Jiangke
Source:
Natural product research 2019 v.33 no.9 pp. 1304-1309
ISSN:
1478-6427
Subject:
Bacillus subtilis, Micrococcus luteus, Proteus vulgaris, Sophora tonkinensis, Xylaria, antibacterial properties, circular dichroism spectroscopy, endophytes, fungi, minimum inhibitory concentration, sesquiterpenoids, spectral analysis
Abstract:
A new eremophilane sesquiterpene, xylareremophil (1), together with five known eremophilanes, 1α,10α-epoxy-3α-hydroxyeremophil-7(11)-en-12,8β-olide (2), 1,10α,13-trihydroxyeremophil-7(11)-en-12,8-olide (3), 1α,10α-epoxy-13-hydroxyeremophil-7(11)-en-12,8β-olide (4), mairetolides B (5) and G (6) were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from Sophora tonkinensis. Their structures were elucidated on the basis of spectroscopic data analysis. The absolute configurations of 1 was determined by comparing computed electronic circular dichroism (ECD) and optical rotation (OR) with experimental results. Compounds 1, 5 and 6 showed antibacterial activities against Proteus vulgaris, Micrococcus luteus, Micrococcus lysodeikticus and Bacillus subtilis with MIC values of 25–100 μg/mL.
Agid:
6444720