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Inter-kingdom signaling between gut microbiota and their host

Li, Qing, Ren, Yixing, Fu, Xiangsheng
Cellular and molecular life sciences 2019 v.76 no.12 pp. 2383-2389
T-lymphocytes, bacteria, dendritic cells, digestive tract mucosa, epinephrine, epithelial cells, humans, intestinal microorganisms, macrophages, neutrophils, norepinephrine, quorum sensing
The crosstalk between prokaryotic bacteria and eukaryotic gut epithelial cells has opened a new field for research. Quorum sensing system (QS) molecules employed by gut microbiota may play an essential role in host–microbial symbioses of the gut. Recent studies on the gut microbiome will unveil evolved mechanisms of the host to affect bacterial QS and shape bacterial composition. Bacterial autoinducers (AIs) could talk to the host’s gut by eliciting proinflammatory effects and modulating the activities of T lymphocyte, macrophage, dendritic cells, and neutrophils. In addition, the gut mucosa could interfere with bacterial AIs by degrading them or secreting AI mimics. Moreover, bacterial AIs and gut hormones epinephrine and noradrenaline may be interchangeable in the crosstalk between the microbiota and human gut. Therefore, inter-kingdom signaling between gut microbiota and host may provide a novel target in the management of gut microbiota-related conditions or diseases in the future.