PubAg

Main content area

Synthesis of functionalized tetrahydrofuran derivatives from 2,5-dimethylfuran through cascade reactions

Author:
Li, J., Muller, E., Pera-Titus, M., Jérôme, F., De Oliveira Vigier, K.
Source:
Green chemistry 2019 v.21 no.10 pp. 2601-2609
ISSN:
1463-9270
Subject:
aldehydes, catalysts, condensation reactions, green chemistry, moieties, tetrahydrofuran
Abstract:
A three-step strategy is proposed for the functionalization of the methyl group of 2,5-dimethylfuran, encompassing the ring opening of 2,5-dimethylfuran to 2,5-hexanedione, its further aldol condensation with aldehydes, and hydrogenation–cyclization of the condensation intermediate to generate alkylated tetrahydrofuran. Active and selective catalysts could be identified for the aldol condensation and hydrogenation–cyclization reactions.
Agid:
6448077