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Synthesis of functionalized tetrahydrofuran derivatives from 2,5-dimethylfuran through cascade reactions
- Li, J., Muller, E., Pera-Titus, M., Jérôme, F., De Oliveira Vigier, K.
- Green chemistry 2019 v.21 no.10 pp. 2601-2609
- aldehydes, catalysts, condensation reactions, green chemistry, moieties, tetrahydrofuran
- A three-step strategy is proposed for the functionalization of the methyl group of 2,5-dimethylfuran, encompassing the ring opening of 2,5-dimethylfuran to 2,5-hexanedione, its further aldol condensation with aldehydes, and hydrogenation–cyclization of the condensation intermediate to generate alkylated tetrahydrofuran. Active and selective catalysts could be identified for the aldol condensation and hydrogenation–cyclization reactions.