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Quercetin-modified gold-palladium nanoparticles as a potential autophagy inducer for the treatment of Alzheimer's disease

Author:
Liu, Yanan, Zhou, Hui, Yin, Tiantian, Gong, Youcong, Yuan, Guanglong, Chen, Lanmei, Liu, Jie
Source:
Journal of colloid and interface science 2019 v.552 pp. 388-400
ISSN:
0021-9797
Subject:
Alzheimer disease, autophagy, biocompatibility, blood-brain barrier, cytotoxicity, lysosomes, nanoparticles, neurotoxicity, pathogenesis, permeability, polysorbates, quercetin
Abstract:
At present, autophagic dysfunction has been considered to be involved in the pathogenesis of Alzheimer’s disease (AD). Thus, the activation of autophagy provides a potential means of eliminating the intracellular amyloid-β (Aβ) and slows down the neurotoxicity induced by Aβ. Here, we synthesize a Quercetin (Qu) modified polysorbate 80 (P-80)-coated AuPd core-shell structure. Our results indicate that Concave cubic Qu@P-80@AuPd can activate autophagy of SH-SY5Y cells, promote the fusion of autophagosomes and lysosomes, accelerate the clearance of Aβ, and protect SH-SY5Y cells from Aβ-induced cytotoxicity damage. Furthermore, Concave cubic Qu@P-80@AuPd also has good biocompatibility and high blood-brain barrier (BBB) permeability. Therefore, we anticipate that Concave cubic Qu@P-80@AuPd will be used as a potential autophagy inducer to treat AD.
Agid:
6448477