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Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra

Author:
Shubina, Larisa Kimovna, Makarieva, Tatyana Nikolaevna, von Amsberg, Gunhild, Denisenko, Vladimir Anatolievich, Popov, Roman Sergeevich, Dyshlovoy, Sergey Anatolievich
Source:
Natural product research 2019 v.33 no.10 pp. 1415-1422
ISSN:
1478-6427
Subject:
Porifera, additive effect, alkaloids, antineoplastic activity, cisplatin, cytotoxicity, guanidines, neoplasm cells, spectral analysis
Abstract:
A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.
Agid:
6453317