Jump to Main Content
Triarylalkenes from the site-selective reductive cross-coupling of benzophenones and aldehydes
- Arkhypchuk, Anna I., D'Imperio, Nicolas, Ott, Sascha
- Chemical communications 2019 v.55 no.43 pp. 6030-6033
- aldehydes, ambient temperature, benzophenones, cross-coupling reactions, transition elements
- PhP(Li)TMS converts benzophenones to phosphaalkenes which upon activation under oxidizing, basic conditions react with aromatic aldehydes under the formation of triarylalkenes. The one-pot reaction omits transition metals, proceeds at room temperature and precludes the formation of any homo-coupling products. Systematic substrate variations reveal reactivity patterns that are useful for the identification of ketone/aldehyde combinations that can be coupled in yields up to 80%.