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Triarylalkenes from the site-selective reductive cross-coupling of benzophenones and aldehydes

Author:
Arkhypchuk, Anna I., D'Imperio, Nicolas, Ott, Sascha
Source:
Chemical communications 2019 v.55 no.43 pp. 6030-6033
ISSN:
1364-548X
Subject:
aldehydes, ambient temperature, benzophenones, cross-coupling reactions, transition elements
Abstract:
PhP(Li)TMS converts benzophenones to phosphaalkenes which upon activation under oxidizing, basic conditions react with aromatic aldehydes under the formation of triarylalkenes. The one-pot reaction omits transition metals, proceeds at room temperature and precludes the formation of any homo-coupling products. Systematic substrate variations reveal reactivity patterns that are useful for the identification of ketone/aldehyde combinations that can be coupled in yields up to 80%.
Agid:
6453407