Main content area

MP-PIC simulation of blood cell movement through a LAD with high stenosis

Liu, Jian, Yu, Fan, Zhang, Yu
Powder technology 2019
angiography, cell movement, computed tomography, coronary vessels, erythrocytes, fluid mechanics, males, models, patients, powders, surface area
Computed Tomography Angiography (CTA)-based computational fluid dynamics (CFD) has been proposed as a non-invasive method for the diagnosis of coronary artery stenosis. Although blood contains a huge amount of blood cells, it is still treated as a single-phase fluid in most of the current CFD models. This may result in inaccurate estimations of the pressure drop through a stenotic artery. In this study, a multiphase particle in cell (MP-PIC) model that includes particle movement in fluid, was proposed to simulate the pressure drop through coronary artery stenosis. A male patient with high stenosis at his left anterior descending (LAD) was chosen as a patient-specific model. Both conventional single-phase model and MP-PIC were used to simulate the pressure drop at this patient-specific model. Specifically, two types of spherical particles were used in MP-PIC to represent the non-spherical red blood cells. Particle 1 has the equivalent volume while particle 2 has the equivalent surface area of a red blood cell. The comparison of simulation results and clinical invasive measurement showed that the single-phase fluid model greatly underestimated the pressure drop; the predicted pressure drop is 6 mm Hg while the measured pressure drop is 20 mm Hg. Particle model 1 also underestimated the pressure drop (15 mm Hg) while particle model 2 overestimated the pressured drop (25 mm Hg). This study indicated that accurate estimation of pressure drop through artery stenosis requires reasonable multiphase models.