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Copper-catalyzed denitrogenative N-arylation of sulfoximines and sulfonamides with arylhydrazines

Author:
Dong, Wanrong, Liu, Chaoyang, Ma, Xinchi, Zhang, Yingjun, Peng, Zhihong, Xie, Dexun, An, Delie
Source:
Tetrahedron 2019
ISSN:
0040-4020
Subject:
arylation, free radicals, moieties, sulfonamides
Abstract:
A Cu-mediated ligand-free arylation of NH-sulfoximines and sulfonamides by arylhydrazine hydrochlorides was herein demonstrated. The oxidative transformation provided an easy access towards N-aryl sulfoximines and sulfonamides in high yields (up to 93% yields) with broad functional groups tolerance (up to 36 examples). The protocol was proposed to take place through the free radical pathway based on the results of control reactions and EPR analysis.
Agid:
6454280