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New cathepsin V inhibitor from stems of Bowdichia virgilioides

Author:
Silva, Taynara L., Fernandes, João B., Silva, M. Fátima das G.F. da, Consolaro, Helder N., Sousa, Lorena R.F. de, Vieira, Paulo C.
Source:
Revista Brasileira de Farmacognosia 2019
ISSN:
0102-695X
Subject:
Bowdichia, beta-sitosterol, cathepsin V, ethyl acetate, fractionation, hexane, lupeol, nuclear magnetic resonance spectroscopy, p-coumaric acid, stems, stigmasterol
Abstract:
Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, β-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydroxy-7-methoxyisoflavone, 7,3′-dihydroxy-4′-methoxyisoflavone, and 5,4′-dihydroxy-7′-methoxyisoflavone. Structures of compounds were stablished by 1D and 2D NMR, and MS experiments. Among the isolated compounds, trans p-coumaric acid ester derivative and 8-methoxycoumestrol showed significant inhibition on cathepsin V, which is up to now unexplored.
Agid:
6454603