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Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice
- Yang, Meilian, Wu, Zihuan, Wang, Yudan, Kai, Guoyin, Singor Njateng, Guy Sedar, Cai, Shengbao, Cao, Jianxin, Cheng, Guiguang
- Food and chemical toxicology 2019 v.131 pp. 110534
- acute toxicity, adverse effects, aerial parts, blood serum, ethanol, histology, kidneys, lethal dose 50, liver, mice, oral administration, spleen, subacute toxicity, toxicity testing
- Acute and subacute toxicities of the ethanol extract from Epigynum auritum (EAE) wereperformed by oral administration in pathogen-free mice. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days, while subacute toxicity test was conducted by daily oral administration of EAE at doses of 312, 625, 1250, and 2500 mg/kg for 28 days. Acute toxicity study showed that LD50 of EAE was over 5000 mg/kg. The results of subacute toxicity showed no significant adverse effect of EAE at 312 mg/kg. Moreover, EAE exhibited toxicities to liver, spleen and kidney in mice determined by hematological, serum biochemical and histological analyses during daily oral administration of 1250 mg/kg and 2500 mg/kg EAE. The results revealed that the dose of EAE lower than 625 mg/kg can be regarded as safe.