PubAg

Main content area

Obesity, weight loss, and its influence on telomere length: New insights for personalized nutrition

Author:
Welendorf, Caroline, Nicoletti, Carolina Ferreira, Pinhel, Marcela Augusta de Souza, Noronha, Natália Yumi, de Paula, Bruna Morais Faleiros, Nonino, Carla Barbosa
Source:
Nutrition 2019 v.66 pp. 115-121
ISSN:
0899-9007
Subject:
adipose tissue, adiposity, biomarkers, cell division, lifestyle, nutrition, obesity, proteins, risk factors, telomeres, weight loss
Abstract:
Telomeres are structures located at the ends of chromosomes associated with proteins, from the shelterin complex, which are responsible for the protection and preservation of the genetic material. The telomere length (TL) progressively decreases with each cell division, and recent evidence suggests that lifestyle can lead to telomere shortening. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. Thus, the aim of the present review was to show the relationship between obesity and TL in addition to the possible risk factors for its shortening and how the different strategies for weight loss can modulate TL. As the crucial result, we can consider the association between TL and weight loss and adiposity changes after different interventions, showing that TL may be used as a biomarker of responses to obesity treatment.
Agid:
6455680