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Uncovering a New Step in Sliding Nucleosomes

Author:
Bowman, Gregory D.
Source:
Trends in biochemical sciences 2019 v.44 no.8 pp. 643-645
ISSN:
0968-0004
Subject:
DNA, histones, nucleosomes
Abstract:
Chromatin remodelers are ATP-driven motors that pump double-stranded DNA around the histone core of the nucleosome. Recent work by Chen and coworkers (Li et al., Nature, 2019 and Yan et al., Nat. Struct. Mol. Biol., 2019) has revealed an unexpected intermediate where initial translocation involves only one of the two DNA strands.
Agid:
6456043