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Chitosan-bound carboxymethylated cotton fabric and its application as wound dressing
- Wang, Yamei, Zhou, Peiwen, Xiao, Dongdong, Zhu, Yuanzhao, Zhong, Yi, Zhang, Jianxiang, Sui, Xiaofeng, Feng, Xueling, Xu, Hong, Mao, Zhiping
- Carbohydrate polymers 2019 v.221 pp. 202-208
- animal models, blood, blood coagulation, carboxymethylcellulose, chitosan, cotton fabric, hemostasis, liver, rats, wound treatment
- Cotton fabric (CF) is commonly used in wound treatment, however, its hemostatic efficiency is far from sufficient. In this study, modified cotton fabric (MCF-0.39) was obtained by a carboxymethylation process, which endowed MCF-0.39 with good swelling ability and water absorption capacity. Chitosan (CHI) was bound to MCF-0.39 by the binder sodium carboxymethyl cellulose (NaCMC) via flat-screen printing technique to prepare the hybrid hemostatic material (CHI-MCF-0.39). The blood clotting index (BCI) of CHI-MCF-0.39 was 3.15-fold lower than that of CF, demonstrating the good clotting ability of the material. In rat liver injury and femoral artery animal model, the groups using CHI-MCF-0.39 had less hemostasis time and blood loss compared with those groups using CF. All the above results indicate that the prepared CHI-MCF-0.39 has promising future applications as effective hemostatic material in trauma treatment.