PubAg

Main content area

Chitosan-bound carboxymethylated cotton fabric and its application as wound dressing

Author:
Wang, Yamei, Zhou, Peiwen, Xiao, Dongdong, Zhu, Yuanzhao, Zhong, Yi, Zhang, Jianxiang, Sui, Xiaofeng, Feng, Xueling, Xu, Hong, Mao, Zhiping
Source:
Carbohydrate polymers 2019 v.221 pp. 202-208
ISSN:
0144-8617
Subject:
animal models, blood, blood coagulation, carboxymethylcellulose, chitosan, cotton fabric, hemostasis, liver, rats, wound treatment
Abstract:
Cotton fabric (CF) is commonly used in wound treatment, however, its hemostatic efficiency is far from sufficient. In this study, modified cotton fabric (MCF-0.39) was obtained by a carboxymethylation process, which endowed MCF-0.39 with good swelling ability and water absorption capacity. Chitosan (CHI) was bound to MCF-0.39 by the binder sodium carboxymethyl cellulose (NaCMC) via flat-screen printing technique to prepare the hybrid hemostatic material (CHI-MCF-0.39). The blood clotting index (BCI) of CHI-MCF-0.39 was 3.15-fold lower than that of CF, demonstrating the good clotting ability of the material. In rat liver injury and femoral artery animal model, the groups using CHI-MCF-0.39 had less hemostasis time and blood loss compared with those groups using CF. All the above results indicate that the prepared CHI-MCF-0.39 has promising future applications as effective hemostatic material in trauma treatment.
Agid:
6457367