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Calaxanthones A-C, three new xanthones from the roots of Calophyllum calaba and the cytotoxicity

Author:
Laopian, Fuengfa, Kaennakam, Sutin, Rassamee, Kitiya, Siripong, Pongpun, Tip-pyang, Santi
Source:
Natural product research 2019 v.33 no.11 pp. 1584-1590
ISSN:
1478-6427
Subject:
Calophyllum calaba, cytotoxicity, human cell lines, inhibitory concentration 50, neoplasm cells, roots, spectral analysis, xanthones
Abstract:
Three new xanthones, named calaxanthones A-C (1–3), along with 17 known xanthones (4–20) were isolated from the roots of Calophyllum calaba. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compound 3 showed potent cytotoxicity against all the five cancer cell lines with IC₅₀ values in the range of 0.82–5.04 μM. Furthermore, compound 6 showed potent cytotoxicity against KB, HeLa S-3 and HepG2 cells with IC₅₀ values of 7.06, 5.27 and 9.64 μM, respectively. Additionally, compound 7 showed potent cytotoxicity against KB cell with an IC₅₀ value of 4.62 μM.
Agid:
6458326