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Chemical constituents and biological activities of Viburnum macrocephalum f. keteleeri

Author:
Shao, Jian-Hua, Chen, Jia, Xu, Xiao-Qing, Zhao, Chun-Chao, Dong, Zi-Ling, Liu, Wen-Yan, Shen, Jie
Source:
Natural product research 2019 v.33 no.11 pp. 1612-1616
ISSN:
1478-6427
Subject:
Mythimna separata, Viburnum macrocephalum, antimicrobial properties, beta-sitosterol, butyrates, chemical composition, fractionation, inhibitory concentration 50, lethal dose 50, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Three new compounds (1–3) and seven known compounds (4–10) have been isolated from the ethanolic extract of Viburnum macrocephalum f. keteleeri using bioactivity-guided fractionation and identified as methyl (2-α-L-rhamnopyranosyloxy)acetate (1), methyl (2R-3-α-L-rhamnopyranosyloxy)glycerate (2), methyl (3R-4-α-L-rhamnopyranosyloxy-3-hydroxy)butanoate (3), bridelionoside B (4), (6S,7E,9R)-roseoside (5), linarionoside A (6), 3,7,11-trimethyl-1,6-dodecadien-3,10,11-triol (7), (+)-8-hydroxylinalool (8), β-sitosterol (9) and daucosterol (10). The structures of 1–3, including absolute configurations, were determined by spectroscopic data (¹H and ¹³C NMR, HSQC, HMBC and ORD) and chemical methods. In addition, compounds 1–8 were assayed for their insecticidal and antimicrobial activities. Compounds 7 and 8 exhibited moderately insecticidal effects against Mythimna separata with LD₅₀ values of 180 and 230 μg g⁻¹, respectively. Compounds 2, 3, 7 and 8 showed varying antimicrobial activities with IC₅₀ values ranging from 125 to 529 μM.
Agid:
6458338