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Furylhydroquinones and miscellaneous compounds from the roots of Lithospermum erythrorhizon and their anti-inflammatory effect in HaCaT cells
- Ahn, Jongmin, Chae, Hee-Sung, Chin, Young-Won, Kim, Jinwoong
- Natural product research 2019 v.33 no.12 pp. 1691-1698
- Lithospermum erythrorhizon, anti-inflammatory activity, inflammation, interleukin-6, nuclear magnetic resonance spectroscopy, roots, tumor necrosis factor-alpha, uridine
- One new furylhydroquinone derivative (1) and seven known compounds (2–8) were isolated from the roots of Lithospermum erythrorhizon Sieb. et Zucc (Boraginaceae). The structure of 1 was elucidated by extensive spectroscopic methods using NMR and MS. The absolute configuration of shikonofuran J (1) was unambiguously determined by aid of comparison experimental ECD with predicted ECD spectra. All the isolates were tested for their inhibitory activities against IL-6 production in HaCaT cells stimulated by tumor necrosis factor (TNF)-α. It was found that gracicleistanthoside (5) and uridine (7) remarkably down-regulated the TNF-α-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation, in HaCaT cells.