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Pd-catalyzed enantioselective cyclopropanation of nitriles with mono substituted allyl carbonates enabled by the bulky N-heterocyclic carbene ligand

Author:
Zhang, Gao-Peng, Huang, Shuai, Jiang, Yang-Jie, Liu, Xiu-Yan, Ding, Chang-Hua, Wei, Yin, Hou, Xue-Long
Source:
Chemical communications 2019 v.55 no.45 pp. 6449-6452
ISSN:
1364-548X
Subject:
allylation, carbenes, carbonates, catalysts, catalytic activity, enantioselectivity, heterocyclic nitrogen compounds, ligands, nitriles, palladium
Abstract:
A highly efficient catalyst for Pd-catalyzed cyclopropanation was developed using a bulkier N-heterocyclic carbene ligand, with which the nitriles reacted with mono substituted allyl reagents to afford cyclopropanes in high yields with high cyclopropanation/allylation and enantioselectivities. The reasons for cyclopropanation were investigated and the usefulness of the products was demonstrated.
Agid:
6458828