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Synchronous screening of multiplexed biomarkers of Alzheimer's disease by a length-encoded aerolysin nanopore-integrated triple-helix molecular switch
- Zou, Zhen, Yang, Hua, Yan, Qi, Qi, Peng, Qing, Zhihe, Zheng, Jing, Xu, Xuan, Zhang, Lihua, Feng, Feng, Yang, Ronghua
- Chemical communications 2019 v.55 no.45 pp. 6433-6436
- Alzheimer disease, biomarkers, chemical compounds, chemical reactions, nanopores, oligonucleotides, screening, signal transduction
- Herein, we developed a versatile strategy for the synchronous screening of biomarkers of Alzheimer's disease (AD) by incorporating the high-resolution discrimination of an aerolysin nanopore to length-encoded oligonucleotides and the signal transduction of a triple-helix molecular switch (TMS). This assay is adapted to quantitatively compare multiplexed targets of very different native contents without tedious chemical labelling.