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Copper-catalyzed regioselective alkylation of heteroarenes with functionalized alkyl halides
- Li, Dengke, Yang, Wen-Chao
- Tetrahedron letters 2019 v.60 no.27 pp. 1792-1795
- alkylation, coumarin, free radicals, moieties, naphthoquinones, organic halogen compounds, quinolones, regioselectivity
- The Cu-catalyzed regioselective alkylation of heteroarenes with functionalized primary, secondary, and tertiary alkyl halides is reported. The reaction proceeds via the copper-catalyzed addition of alkyl radicals to a wide range of heteroarenes, including coumarin, quinolinone, naphthoquinone, and benzofuran derivatives, with a broad substrate scope and wide functional group tolerance.