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A brief history of artemisinin: Modes of action and mechanisms of resistance

Author:
LU, Feng, HE, Xin-Long, Richard, Culleton, CAO, Jun
Source:
Chinese journal of natural medicines 2019 v.17 no.5 pp. 331-336
ISSN:
1875-5364
Subject:
Oriental traditional medicine, Plasmodium falciparum, artemisinin, malaria, mechanism of action, morbidity, mortality, parasites
Abstract:
The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug, its use both historically and currently, and our current understanding of its mode of action and the mechanisms by which malaria parasites achieve resistance.
Agid:
6462695