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Six new monacolin analogs from red yeast rice

Author:
LIU, Bing-Yu, XU, Fei, BAI, Jian, YAN, Dao-Jiang, ZHANG, Le, ZHANG, Dan, HU, You-Cai
Source:
Chinese journal of natural medicines 2019 v.17 no.5 pp. 394-400
ISSN:
1875-5364
Subject:
3-hydroxybutyric acid, Oriental traditional medicine, antioxidant activity, circular dichroism spectroscopy, ethyl acetate, lipid peroxidation, lipopolysaccharides, liver, monacolins, nitric oxide, nuclear magnetic resonance spectroscopy, rats, red yeast rice, spectral analysis
Abstract:
Six novel monacolin analogs, monacolins V1–V6 (1–6), together with seven known ones (7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (1H-1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V2 (2) and V3 (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
Agid:
6462703