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Fluoro-functionalized paper-based solid-phase extraction for analysis of perfluorinated compounds by high-performance liquid chromatography coupled with electrospray ionization–tandem mass spectrometry

He, Xiaowei, He, Yan, Huang, Si, Fang, Zhengfa, Liu, Jingjing, Ma, Ming, Chen, Bo
Journal of chromatography 2019 v.1601 pp. 79-85
adsorbents, biodegradability, detection limit, electrospray ionization mass spectrometry, high performance liquid chromatography, paper, perfluorocarbons, perfluorooctane sulfonic acid, perfluorooctanoic acid, river water, solid phase extraction, tandem mass spectrometry, tap water, wastewater
Fluoro-functionalized paper was prepared and applied in solid phase extraction (SPE) for the analysis of trace-level perfluorinated compounds (PFCs). The proposed fluoro-functionalized paper-based solid-phase extraction (Fp-SPE) exhibits significant advantages for sample preparation, such as the biodegradability of paper-based adsorbent, simple manipulation and low cost. Owing to the fluorous affinity, the Fp-SPE technique with high sensitivity and high selectivity is more suitable for the selective enrichment of fluorine-containing molecules from the background of non-fluorinated organic compounds in a real water sample. Combined with high-performance liquid chromatography coupled with electrospray ionization-tandem mass spectrometry analysis (HPLC-MS/MS), the linear range of the PFCs, including perfluorobutyric acid (PFBA), perfluorooctanic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorodecanoic acid (PFDA), was 0.20–5.0 ng/L with the limits of detection (LOD) ranging from 0.04–0.05 ng/L and the limits of quantification (LOQ) ranging from 0.15-0.20 ng/L. The method was then applied to the analysis of tap water, river water and waste water samples. The results of the actual sample analysis are consistent with that by reverse phase SPE (RP-SPE).