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A β-1,3/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator

Author:
Fan Su, Qiaoling Song, Chuanliang Zhang, Xiaohan Xu, Mengyuan Li, Dan Yao, Lijuan Wu, Xianjun Qu, Huashi Guan, Guangli Yu, Jinbo Yang, Chenyang Zhao
Source:
Carbohydrate polymers 2019 v.222 pp. 114993
ISSN:
0144-8617
Subject:
Durvillaea, algae, antibodies, antineoplastic activity, beta-glucans, cell lines, chemokines, inflammation, macrophages, models, neoplasm progression, neoplasms, phagocytosis, secretion, Antarctica
Abstract:
β-glucans trigger the proinflammatory responses of innate immune cells to enhance the host defense. A variety of β-glucans were identified as strong immune stimulator and exerted antitumor activities. Our previous work indicates that a β-1,3/1,6-glucan (BG136) derived from marina alga Durvillaea antarctica promotes the proinflammatory responses in macrophage cell line RAW264.7. In the present study, we further explored its antitumor effects in vivo as an immune stimulator. The data shows that BG136 alone decreases the tumor burdens in DLD1 xenograft and AOM-DSS induced tumor models. BG136 also augments the antitumor effects of PD-1 antibody in B16 syngeneic tumor model. BG136 increases macrophage phagocytosis, enhances cytokine/chemokine secretion and modulates the systemic and intratumoral immune cell composition. Collectively, these data suggest that BG136 might act as an immune stimulator to exert antitumor effects in vivo.
Agid:
6466151