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Polyunsaturated fatty acids from microalgae Spirulina platensis modulates lipid metabolism disorders and gut microbiota in high-fat diet rats

Author:
Li, Tian-Tian, Tong, Ai-Jun, Liu, Yuan-Yuan, Huang, Zi-Rui, Wan, Xu-Zhi, Pan, Yu-Yang, Jia, Rui-Bo, Liu, Bin, Chen, Xin-Hua, Zhao, Chao
Source:
Food and chemical toxicology 2019 v.131 pp. 110558
ISSN:
0278-6915
Subject:
Arthrospira platensis, Prevotella, blood serum, cholesterol, ethanol, functional foods, genes, high fat diet, hyperlipidemia, intestinal microorganisms, lipid metabolism, liver, low density lipoprotein, mass spectrometry, messenger RNA, microalgae, polyunsaturated fatty acids, protein synthesis, rats, toxicology, triacylglycerols, ultra-performance liquid chromatography
Abstract:
Effects of Spirulina platensis 55% ethanol extract (SPL55) on lipid metabolism in high-fat diet-induced hyperlipidaemic rats were investigated. Ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry indicated that SPL55 was enriched with polyunsaturated fatty acids. Meanwhile, serum and liver lipid levels, including total triglyceride, total cholesterol, and low-density-lipoprotein cholesterol, were significantly decreased in hyperlipidaemic rats of SPL55. Analysis of tissue sections showed that SPL55 treatment could markedly inhibit hepatic lipid accumulation and steatosis. Moreover, SPL55 regulated the mRNA and protein expression levels of SREBP-1c, HMG-CoA, PEPCK, ACC, and AMPK genes involved in lipid metabolism. Furthermore, SPL55 led to decrease the abundances of Turicibacter, Clostridium_XlVa, and Romboutsia, which were positive correlation with lipid metabolism indicators, and has also enriched Alloprevotella, Prevotella, Porphyromonadaceae, and Barnesiella. These results provided evidence that SPL55 might be developed as a functional food to ameliorate lipid metabolic disorders and hyperlipidaemia.
Agid:
6466451