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Toxic effects and metabolic fate of carbamazepine in diatom Navicula sp. as influenced by humic acid and nitrogen species

Author:
Ding, Tengda, Lin, Kunde, Yang, Bo, Yang, Menting, Li, Juying
Source:
Journal of hazardous materials 2019 v.378 pp. 120763
ISSN:
0304-3894
Subject:
Navicula, algae, algae culture, ammonium, demethylation, humic acids, hydroxylation, median effective concentration, metabolites, nitrogen, surface water, toxicity
Abstract:
Carbamazepine (CAB) is a commonly detected pharmaceutical in the surface waters. In the present study, we evaluated the effect of humic acid (HA) and nitrogen species on the toxicity of CAB in a typical diatom Navicula sp., and its metabolic fate. The Navicula sp. showed a high sensitivity to CAB (72 h EC50 = 0.179 mg L−1). The addition of HA (< 30 mg L−1) and ammonium could promote the growth of Navicula sp. during 6 d of exposure to CAB. CAB underwent rapid dissipation in the algal culture. The degradation of CAB in Navicula sp. cultures was significantly increased by the addition of HA and higher HA contents caused more degradation of CAB. Degradation and accumulation of CAB in Navicula sp. were significantly inhibited by ammonium. Five metabolites were found and possible degradation pathways of CAB in the algal cell were proposed. Methoxylation, demethylation, glucuronidation and hydroxylation contributed to CAB transformation in the algal cell.
Agid:
6466554