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Candidalysin: discovery and function in Candida albicans infections

Author:
Naglik, Julian R, Gaffen, Sarah L, Hube, Bernhard
Source:
Current opinion in microbiology 2019 v.52 pp. 100-109
ISSN:
1369-5274
Subject:
Candida albicans, animal pathogenic fungi, candidiasis, immune response, neutrophils, pathogenesis, peptides, virulence
Abstract:
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.
Agid:
6467428