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Effect of α2-adrenoceptor antagonism on the minimum alveolar concentration of isoflurane in cats

Author:
Pypendop, Bruno H., Ahokoivu, Hanna, Honkavaara, Juhana
Source:
Veterinary anaesthesia and analgesia 2019
ISSN:
1467-2987
Subject:
adults, agonists, alpha-2 adrenergic receptors, anesthesia, antagonism, breathing, cats, isoflurane, males, oxygen, tail
Abstract:
To characterize the effect of α2-adrenoceptor antagonism on the minimum alveolar concentration of isoflurane (MACISO) in cats.Prospective experimental study.A group of five healthy adult male neutered cats.Cats were anesthetized with isoflurane in oxygen and instrumented. MACISO was determined in duplicate in five cats, before and during administration of atipamezole (250 μg kg−1 followed by 250 μg kg−1 hour−1) using the bracketing technique and tail clamping. Estimates of MACISO obtained before and during administration of atipamezole were compared using a two-tailed paired t test.MACISO during atipamezole administration (mean ± standard deviation 2.73% ± 0.07%) was significantly larger than before atipamezole administration (1.95% ± 0.13%; p < 0.0001).The role of α2-adrenoceptors in inhaled anesthetic-induced immobility may be larger than previously thought. Antagonism of an α2-adrenoceptor agonist during inhalation anesthesia may result in an increase in MAC disproportionate to the MAC reduction induced by the agonist.
Agid:
6467462