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Rh(iii)-Catalyzed straightforward arylation of 8-methyl/formylquinolines using diazo compounds
- Ghosh, Bidhan, Samanta, Rajarshi
- Chemical communications 2019 v.55 no.48 pp. 6886-6889
- arylation, diazo compounds, moieties, phenol, quinones, regioselectivity, rhodium
- A straightforward Rh(iii)-catalyzed general strategy was developed for the introduction of naphthol/phenol moieties to the C(sp³)–H bond of 8-methylquinoline using diazonaphthalen-2(1H)-ones/quinone diazides. The developed method was further extended towards the arylation of 8-formylquinolines to accomplish diarylketone derivatives. The method is simple, relatively rapid, and chemo and regioselective with a wide scope and functional group tolerance. The synthetic utility was established through gram-scale synthesis and biologically active molecule construction.