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A fluorogenic BODIPY molecular rotor as an apoptosis marker
- AshokkumarThese authors contributed equally to this work., Pichandi, Ashoka, Anila Hoskere, Collot, Mayeul, Das, Amitava, Klymchenko, Andrey S.
- Chemical communications 2019 v.55 no.48 pp. 6902-6905
- apoptosis, chemical compounds, chemical reactions, fluorescence, molecular rotors, phosphatidylserines
- Based on a BODIPY molecular rotor and a zinc–dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.