PubAg

Main content area

A fluorogenic BODIPY molecular rotor as an apoptosis marker

Author:
AshokkumarThese authors contributed equally to this work., Pichandi, Ashoka, Anila Hoskere, Collot, Mayeul, Das, Amitava, Klymchenko, Andrey S.
Source:
Chemical communications 2019 v.55 no.48 pp. 6902-6905
ISSN:
1364-548X
Subject:
apoptosis, chemical compounds, chemical reactions, fluorescence, molecular rotors, phosphatidylserines
Abstract:
Based on a BODIPY molecular rotor and a zinc–dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.
Agid:
6467776