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Heterogeneous growth of palladium nanocrystals on upconversion nanoparticles for multimodal imaging and photothermal therapy

ZhaoHuijun Zhao and Lei Zhao contributed equally to this work., Huijun, Zhao, Lei, Wang, Zhuo, Xi, Wensong, Dibaba, Solomon Tiruneh, Wang, Shuhan, Shi, Liyi, Sun, Lining
Journal of materials chemistry B 2019 v.7 no.23 pp. 3652-3660
biocompatibility, erbium, gadolinium, human cell lines, image analysis, ions, irradiation, luminescence, magnetic resonance imaging, nanocomposites, nanocrystals, nanoparticles, neoplasms, palladium, photothermotherapy, physical therapy
Nanocomposites have been playing an increasingly significant role in the bioimaging-guided visualization of cancer physiotherapy. However, it has been a challenge to explore new diagnosis and treatment reagents with small size, good stability, and high photothermal conversion efficiency. Herein, we report a novel preparation of nanocomposites based on the heterogeneous growth of nano-palladium on the surface of upconversion nanoparticles (UCNPs). The final poly vinylpyrrolidone (PVP) modified UCNPs@Pd nanocomposites possess a small size and exhibit good monodispersity, biocompatibility and high photothermal conversion efficiency. In addition, relevant cellular assays show that based on the growth of palladium, the UCNPs@Pd-PVP nanocomposites can effectively kill HeLa cells under 808 nm laser irradiation. The nanocomposites also present effective upconversion luminescence imaging and T₁ signal enhancement capability based on Er³⁺ and Gd³⁺ ions, respectively. Therefore, the nanocomposites successfully integrate upconversion luminescence imaging, magnetic resonance imaging, and photothermal therapy. This work provides new insights for the future development of multi-application materials based on the multicomponent heterogeneous growth of nanocomposites.