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Heterogeneous growth of palladium nanocrystals on upconversion nanoparticles for multimodal imaging and photothermal therapy
- ZhaoHuijun Zhao and Lei Zhao contributed equally to this work., Huijun, Zhao, Lei, Wang, Zhuo, Xi, Wensong, Dibaba, Solomon Tiruneh, Wang, Shuhan, Shi, Liyi, Sun, Lining
- Journal of materials chemistry B 2019 v.7 no.23 pp. 3652-3660
- biocompatibility, erbium, gadolinium, human cell lines, image analysis, ions, irradiation, luminescence, magnetic resonance imaging, nanocomposites, nanocrystals, nanoparticles, neoplasms, palladium, photothermotherapy, physical therapy
- Nanocomposites have been playing an increasingly significant role in the bioimaging-guided visualization of cancer physiotherapy. However, it has been a challenge to explore new diagnosis and treatment reagents with small size, good stability, and high photothermal conversion efficiency. Herein, we report a novel preparation of nanocomposites based on the heterogeneous growth of nano-palladium on the surface of upconversion nanoparticles (UCNPs). The final poly vinylpyrrolidone (PVP) modified UCNPs@Pd nanocomposites possess a small size and exhibit good monodispersity, biocompatibility and high photothermal conversion efficiency. In addition, relevant cellular assays show that based on the growth of palladium, the UCNPs@Pd-PVP nanocomposites can effectively kill HeLa cells under 808 nm laser irradiation. The nanocomposites also present effective upconversion luminescence imaging and T₁ signal enhancement capability based on Er³⁺ and Gd³⁺ ions, respectively. Therefore, the nanocomposites successfully integrate upconversion luminescence imaging, magnetic resonance imaging, and photothermal therapy. This work provides new insights for the future development of multi-application materials based on the multicomponent heterogeneous growth of nanocomposites.