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A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas
- XuThese authors contributed equally to this work., Xiaoying, Liu, Kang, Wang, Yue, Zhang, Changchang, Shi, Menghan, Wang, Peng, Shen, Linghong, Xia, Jindong, Ye, Ling, Shi, Xiangyang, Shen, Mingwu
- Journal of materials chemistry B 2019 v.7 no.23 pp. 3639-3643
- blood-brain barrier, brain, chelates, chemistry, dendrimers, glioma, image analysis, manganese, nanogold, neoplasm cells, peptides
- An RGD peptide-targeted low-generation dendrimer-based nanoprobe has been developed through the versatile dendrimer nanotechnology. The poly(amidoamine) dendrimers of generation 2 can be modified or loaded with Mn chelates, RGD peptide, and gold nanoparticles to have desired stability, cytocompatibility, cancer cell targeting specificity, and ability to cross the blood-brain barrier for targeted MR/CT imaging of an orthotopic brain glioma.