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Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats

Author:
Dastan, Dara, Karimi, Sedigheh, Larki-Harchegani, Amir, Nili-Ahmadabadi, Amir
Source:
Environmental science and pollution research international 2019 v.26 no.18 pp. 18886-18892
ISSN:
0944-1344
Subject:
Allium, antioxidant activity, antioxidants, blood serum, bulbs, cadmium, colorimetry, creatinine, drinking water, kidneys, lipid peroxidation, nitric oxide, oxidative stress, protective effect, rats, renal failure, renal function, thiols, toxicity, uric acid
Abstract:
Cadmium (Cd), as a toxic metal, can accumulate in kidneys and induce renal failure. This study was undertaken to evaluate the protective effects of Allium hirtifolium Boiss bulbs against Cd-induced renal failure in rats. Thirty-six rats were divided into 6 groups: group 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and AhB extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which treated AhB extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, renal function and oxidative stress markers were determined by using colorimetric methods. Our findings showed that Cd caused a significant increase in creatinine (Cr; p<0.05), uric acid (p<0.01), BUN (p<0.05), serum levels, lipid peroxidation (LPO; p<0.01), and nitric oxide (NO; p<0.01); the depletion of the total antioxidant capacity (TAC; p<0.01) and total thiol molecules (TTM; p<0.001); and structural alterations in the renal tissue. Following AhB extract administration, a remarkable improvement was observed in the functional and oxidative stress markers of renal tissue.This study suggests that AhB may prevent progression of Cd-induced renal failure via improvement of oxidative/antioxidant balance in renal tissue.
Agid:
6470708