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Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats

Dastan, Dara, Karimi, Sedigheh, Larki-Harchegani, Amir, Nili-Ahmadabadi, Amir
Environmental science and pollution research international 2019 v.26 no.18 pp. 18886-18892
Allium, antioxidant activity, antioxidants, blood serum, bulbs, cadmium, colorimetry, creatinine, drinking water, kidneys, lipid peroxidation, nitric oxide, oxidative stress, protective effect, rats, renal failure, renal function, thiols, toxicity, uric acid
Cadmium (Cd), as a toxic metal, can accumulate in kidneys and induce renal failure. This study was undertaken to evaluate the protective effects of Allium hirtifolium Boiss bulbs against Cd-induced renal failure in rats. Thirty-six rats were divided into 6 groups: group 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and AhB extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which treated AhB extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, renal function and oxidative stress markers were determined by using colorimetric methods. Our findings showed that Cd caused a significant increase in creatinine (Cr; p<0.05), uric acid (p<0.01), BUN (p<0.05), serum levels, lipid peroxidation (LPO; p<0.01), and nitric oxide (NO; p<0.01); the depletion of the total antioxidant capacity (TAC; p<0.01) and total thiol molecules (TTM; p<0.001); and structural alterations in the renal tissue. Following AhB extract administration, a remarkable improvement was observed in the functional and oxidative stress markers of renal tissue.This study suggests that AhB may prevent progression of Cd-induced renal failure via improvement of oxidative/antioxidant balance in renal tissue.