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Acute, genetic and sub-chronic toxicities of flaxseed derived Maillard reaction products

Author:
Wei, Chao-Kun, Ni, Zhi-Jing, Thakur, Kiran, Liao, Ai-Mei, Hu, Fei, Huang, Ji-Hong, Wei, Zhao-Jun
Source:
Food and chemical toxicology 2019 v.131 pp. 110580
ISSN:
0278-6915
Subject:
Ames test, Maillard reaction products, acute toxicity, blood chemistry, body weight, flavorings, food intake, hematology, histology, lethal dose 50, linseed, meat, mortality, mutagenicity, rats, spermatozoa
Abstract:
In present study, the acute, genetic, and sub-chronic toxicities of flaxseed derived Maillard reaction products (MRPs) were investigated. Acute toxicity results showed that the 50% lethal dose (LD50) of MRPs in rats was >15.0 g/kg body weight (BW); whereas, the 50% effective dose (ED50) of MRPs was 12.3 g/kg BW. Ames test demonstrated that the back-mutation colonies for MRPs addition of 5,000 μg/dish was positive, which displayed certain mutagenicity. There were no significant differences in micronucleus rate and sperm deformity rate among different dose groups. The sub-chronic toxicity confirmed that less than 0.75 gMRPs/kg BW intake did not affect weight, food intake, mortality, gross pathology, histology, hematology, and serum biochemistry. The obtained results can provide an imperative reference on the safety of a meat flavoring agents.
Agid:
6471291