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Phytochemical characterization and biological activity of secondary metabolites from three Limonium species

Author:
Anastassiya V. Gadetskaya, Shaymaa M. Mohamed, Amer H. Tarawneh, Nesma Mohamed, Guoyi Ma, Boris Ponomarev, Galiya E. Zhusupova, Charles L. Cantrell, Stephen J. Cutler, Samir A. Ross
Source:
Medicinal chemistry research 2017 v.26 no.11 pp. 2743-2750
ISSN:
1054-2523
Subject:
Limonium gmelinii, Trypanosoma brucei, antifungal properties, antitrypanosomal properties, chloroquine, esters, gallic acid, malaria, phytochemicals, secondary metabolites
Abstract:
The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds (2–21). Each species displayed different profiles in their phytochemical constituents. The isolated compounds (1–21) were evaluated for antifungal, antimalarial, and antitrypanosomal activities. Compound 1 showed good activity against chloroquine-resistant and chloroquine-sensitive strains of malaria, while compound 5 displayed moderate antimalarial activity. Compound 14showed a significant activity against Trypanosoma brucei.
Agid:
6472279
Handle:
10113/6472279