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BG-4 from Bitter Gourd (<i>Momordica charantia</i>) Differentially Affects Inflammation In Vitro and In Vivo

Author:
Nieto-Veloza, Andrea, Wang, Zhihong, Zhong, Qixin, Krishnan, Hari B., Dia, Vermont P.
Source:
Antioxidants 2019 v.8 no.6
ISSN:
2076-3921
Subject:
Momordica charantia, anti-inflammatory activity, antineoplastic activity, antioxidants, body weight changes, colitis, colon, comparative study, cytokines, dextran, enzyme activity, feces, in vitro studies, in vivo studies, inflammation, intraperitoneal injection, lipopolysaccharides, macrophages, mice, myeloperoxidase, neutrophils, plant extracts, sodium sulfate
Abstract:
BG-4 isolated from bitter gourd has been reported for anti-cancer properties. The objective was to evaluate the anti-inflammatory properties of BG-4 in vitro and in vivo. Comparative study of the anti-inflammatory properties of BG-4 in vitro and in vivo was conducted on lipopolysaccharide (LPS)-activated mouse macrophages, and on dextran sodium sulfate (DSS)-induced colitis in mice. BG-4 reduced the production of pro-inflammatory markers in LPS-activated macrophages. On the other hand, intraperitoneal administration of BG-4 in DSS-induced colitis led to colon shortening, elevated neutrophils infiltration and myeloperoxidase activity, presence of blood in the stool, and loss of body weight, with differential systemic and local effects on pro-inflammatory cytokines in vivo. The results demonstrated that BG-4 differentially affected inflammation in vitro and in vivo.
Agid:
6472493
Handle:
10113/6472493