Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates
- Source:
- ACS omega 2018 v.3 no.5 pp. 5808-5813
- ISSN:
- 2470-1343
- Subject:
- Trichomonas vaginalis, antiprotozoal properties, chalcone, ferrocenes, indoles, inhibitory concentration 50, microbiome, synthesis, triazoles, trichomoniasis
- Abstract:
- In this study, we outline the synthesis of isatin–ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin–ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 μM. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 μM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.
- Agid:
- 6473320
- Handle:
- 10113/6473320
- https://doi.org/10.1021/acsomega.8b00553