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Phytotoxic Lignans from Artemisia arborescens

Author:
Andrea Labruzzo, Charles Cantrell, Alessandra Carrubba, Abbas Ali, David Wedge, Stephen Duke
Source:
Natural product communications 2018 v.13 no.3 pp. 237-240
ISSN:
1934-578X
Subject:
Aedes aegypti, Agrostis stolonifera, Artemisia, Botrytis cinerea, Colletotrichum acutatum, Fusarium oxysporum, Glomerella cingulata, Lactuca sativa, Lemna aequinoctialis, aerial parts, antifungal properties, bioassays, botanical insecticides, inhibitory concentration 50, insect larvae, insecticidal properties, larvicides, lettuce, lignans, mechanism of action, phytotoxicity, phytotoxins, plant extracts
Abstract:
A systematic bioassay-guided fractionation of methylene chloride extracts of the aerial part of Artemisia arborescens was performed in order to identify its phytotoxic compounds. Two lignans were isolated, sesamin and ashantin, that inhibited growth of Agrostis stolonifera (bentgrass), a monocot, and Lactuca sativa (lettuce), a dicot, at 1 mg mL(-1). In a dose-response screening of these lignans for growth inhibition against Lemna paucicostata (duckweed), ashantin was the most active with an IC(50) of ca. 224 µM. The mode of action of these compounds is still unknown. In mosquito larvicidal bioassays against Aedes aegypti, isolated pure compounds sesamin and ashantin did not show any activity at the highest dose of 125 mg/L against 1-d-old Aedes aegypti larvae. In bioautography bioassays for antifungal activity using Botritis cinerea, Fusarium oxysporum, Colletotrichum fragariae, Colletotrichum acutatum, and Colletotrichum gloeosporioides, ashantin and sesamin were inactive at the highest amount tested, 5 micrograms.
Agid:
6473325
Handle:
10113/6473325