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Circle the Wagons: Circular RNAs Control Innate Immunity
- Wilusz, Jeremy E.
- Cell 2019 v.177 no.4 pp. 797-799
- circular RNA, double-stranded RNA, enzymes, genes, immune response, innate immunity, messenger RNA
- Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to aid in the immune response.