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Chicken egg yolk antibody (IgY) as diagnostics and therapeutics in parasitic infections – A review

Thirumalai, Diraviyam, Visaga Ambi, Senthil, Vieira-Pires, Ricardo S., Xiaoying, Zhang, Sekaran, Saravanan, Krishnan, Umamaheswari
International journal of biological macromolecules 2019 v.136 pp. 755-763
antibodies, chickens, diagnostic techniques, early diagnosis, egg yolk, humans, immunoassays, immunoglobulin G, immunoglobulin Y, immunotherapy, morbidity, mortality, parasites, parasitology, parasitoses
Early diagnosis and treatment of parasitic diseases are indispensable to combat parasites mediated morbidity and mortality in humans and animals. Mammalian sourced antibodies are being successfully used in immunotherapy and immunoassays. However, their increased conservation amongst mammals, involves them in unnecessary interaction and immune mediated pathologies, obstructing their applications in certain approaches in immunoassays. Further, the high production cost and difficulty to achieve high and stable antibody titer hampers their utility for therapeutic purposes. In recent years, chicken egg yolk immunoglobulin, termed as immunoglobulin Y (IgY) has attracted noticeable consideration since it poses greater advantages than mammalian IgG including high yield, low cost and convenience. IgY has unique properties which are being exploited in different aspects for its applications in research, diagnosis and therapy. This review gives an overview of the research outcomes pertaining to chicken IgY as diagnostics and therapeutics in parasitology.