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Recent developments in terminator technology in Saccharomyces cerevisiae
- Matsuyama, Takashi
- Journal of bioscience and bioengineering 2019
- Saccharomyces cerevisiae, fermentation, gene expression, genes, metabolic engineering, organic compounds, promoter regions, sustainable communities, yeasts
- Metabolically engineered microorganisms that produce useful organic compounds will be helpful for realizing a sustainable society. The budding yeast Saccharomyces cerevisiae has high utility as a metabolic engineering platform because of its high fermentation ability, non-pathogenicity, and ease of handling. When producing yeast strains that produce exogenous compounds, it is a prerequisite to control the expression of exogenous enzyme-encoding genes. Terminator region in a gene expression cassette, as well as promoter region, could be used to improve metabolically engineered yeasts by increasing or decreasing the expression of the target enzyme-encoding genes. The findings on terminators have grown rapidly in the last decade, so an overview of these findings should provide a foothold for new developments.