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Pediococcus acidilactici AS185 attenuates early atherosclerosis development through inhibition of lipid regulation and inflammation in rats
- Wang, Chao, Wang, Han, Zhao, Zijian, Xiao, Shan, Zhao, Yujuan, Duan, Cuicui, Gao, Lei, Li, Shengyu, Wang, Jihui
- Journal of functional foods 2019 v.60 pp. 103424
- Pediococcus acidilactici, adhesion, atherosclerosis, blood serum, cholecalciferol, farmers, high fat diet, histopathology, hyperlipidemia, inflammation, intercellular adhesion molecule-1, interferon-gamma, interleukin-10, interleukin-1beta, interleukin-6, lipid composition, lipids, mechanism of action, mitogen-activated protein kinase, models, pathophysiology, probiotics, protective effect, protein synthesis, rats, soybean paste, tumor necrosis factor-alpha, vascular cell adhesion molecules, China
- Pathophysiologic mechanisms underlying atherosclerosis (AS) development are linked to dyslipidemia and inflammation. Pediococcus acidilactici AS185, a probiotic, was isolated from traditional farmers’ soybean paste (Yanji, China). This study aimed to assess P. acidilactici AS185 anti-atherosclerotic effects and elucidate molecular mechanisms of action using an early AS model of SD rats fed a high-fat diet with intraperitoneal vitamin D3 (VD3) injections. For 8 weeks, model rats received P. acidilactici AS185 via gavage once/day. Post-treatment serum levels of inflammatory mediators, lipids, adhesion molecules, aortic histopathological characteristics and AS-related aortic protein expression levels were assessed. P. acidilactici AS185 administration markedly increased serum HDL-C and IL-10 levels, while reducing serum TG, LDL-C, TC, Ox-LDL, ICAM-1, VCAM-1, TNF-α, IFN-γ, IL-1β, and IL-6 levels. Notably, P. acidilactici AS185 inhibited p-p38 and ERK1/2 MAPK pathways and decreased Ox-LDL and CD36 expression to attenuate early AS by altering lipid profiles and MAPK-signaling-based inflammation.