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Ergosterols from Ganoderma sinense and their anti-inflammatory activities by inhibiting NO production

Author:
Ren-Qiang Mei, Feng-Jiao Zuo, Xiao-Yan Duan, Yi-Na Wang, Jun-Rong Li, Cheng-Zhen Qian, Ji-Ping Xiao
Source:
Phytochemistry letters 2019 v.32 pp. 177-180
ISSN:
1874-3900
Subject:
Ganoderma, X-ray diffraction, anti-inflammatory activity, fruiting bodies, inhibitory concentration 50, nitric oxide, nuclear magnetic resonance spectroscopy
Abstract:
Three new ergosterols, ganocalidophins A–C (1‒3), along with four known ones, were isolated from the fruiting bodies of Ganoderma sinense. Their structures were established on the basis of extensive NMR and MS technologies, as well as the single crystal X-ray diffraction. Compounds 1‒3 and 6 exhibited inhibitory activities against NO production with IC50 of 17.7–32.4 μM.
Agid:
6475980