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Fluorescence detection of glutathione S-transferases in a low GSH level environment

Author:
Song, Aiguo, Feng, Tian, Shen, Xin, Gai, Shouchang, Zhai, Yumeng, Chen, Hui
Source:
Chemical communications 2019 v.55 no.50 pp. 7219-7222
ISSN:
1364-548X
Subject:
chemical compounds, chemical reactions, drug resistance, fluorescence, fluorescent dyes, glutathione transferase, neoplasms
Abstract:
Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes, we developed a fluorescent probe enabling the detection of intracellular GSTs in a low GSH level environment by pre-treatment of the cells with thiol-scavengers.
Agid:
6476741