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A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

Author:
Dai, Xin, Zhou, Xueying, Liao, Chunyan, Yao, Yongchao, Yu, Yunlong, Zhang, Shiyong
Source:
Chemical communications 2019 v.55 no.50 pp. 7199-7202
ISSN:
1364-548X
Subject:
aromatic hydrocarbons, chemical reactions, cisplatin, enzyme activity, fluorouracil, glutathione, glutathione transferase, nanomaterials
Abstract:
A nanodrug that can effectively combat cisplatin-resistant A549/CDDP cells was developed by protecting cisplatin from glutathione (GSH) detoxification trough a host–guest interaction between cisplatin and p-sulfonatocalix[4]arene. The enzymatic activity of glutathione S-transferases (GSTs) was also regulated by loaded 5-fluorouracil (5-FU).
Agid:
6476748