Jump to Main Content
A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalixarene and regulating glutathione S-transferases with loaded 5-fluorouracil
- Dai, Xin, Zhou, Xueying, Liao, Chunyan, Yao, Yongchao, Yu, Yunlong, Zhang, Shiyong
- Chemical communications 2019 v.55 no.50 pp. 7199-7202
- aromatic hydrocarbons, chemical reactions, cisplatin, enzyme activity, fluorouracil, glutathione, glutathione transferase, nanomaterials
- A nanodrug that can effectively combat cisplatin-resistant A549/CDDP cells was developed by protecting cisplatin from glutathione (GSH) detoxification trough a host–guest interaction between cisplatin and p-sulfonatocalixarene. The enzymatic activity of glutathione S-transferases (GSTs) was also regulated by loaded 5-fluorouracil (5-FU).