PubAg

Main content area

Bypassing Biocatalytic Substrate Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking

Author:
Milzarek, Tobias M., Einsiedler, Manuel, Aldemir, Hülya, D’Agostino, Paul M., Evers, Julia K., Hertrampf, Gesa, Lamm, Katharina, Malay, Mert, Matura, Anke, Müller, Jonas I., Gulder, Tobias A. M.
Source:
Organic letters 2019 v.21 no.12 pp. 4520-4524
ISSN:
1523-7052
Subject:
aromatic hydrocarbons, biosynthesis, chemical structure, oxidation, unspecific monooxygenase
Abstract:
Enzymatic oxidative dearomatization is an efficient way to generate chiral molecules from simple arenes. One example is the flavin-dependent monooxygenase SorbC involved in sorbicillinoid biosynthesis. However, SorbC requires a long-chain keto substituent at its phenolic substrate, thus preventing its application beyond the synthesis of natural sorbicillinoids or close structural analogues. This work describes an approach to broaden the accessible product spectrum of SorbC by employing an ester functionality mimicking the natural substrate structure during enzymatic oxidation.
Agid:
6478163