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A Pore-Forming Tripeptide as an Extraordinarily Active Anion Channel
- Zeng, Fei, Liu, Fang, Yuan, Lin, Zhou, Shaoyuan, Shen, Jie, Li, Ning, Ren, Haisheng, Zeng, Huaqiang
- Organic letters 2019 v.21 no.12 pp. 4826-4830
- bromides, chemical reactions, chemical structure, chlorides, iodides, lipids, median effective concentration, nitrates, organic compounds, perchlorates, tripeptides
- Compared to the most active anion-transporting channel that requires a channel:lipid molar ratio of 1:330 (0.3 mol % relative to lipid) to achieve 50% activity, a structurally simple pore-forming tripeptide 6L₃10 was found to exhibit an extraordinarily strong ability to self-assemble into stable possibly barrel-shaped exceptionally active channels, with record-low EC₅₀ values of 4.0, 3.0, 1.6, 2.6, and 2.6 nM (e.g., 0.005–0.013 mol % relative to lipid) for Cl–, Br–, I–, NO₃–, and ClO₄–, respectively.