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Pharmacokinetics and acetylcholine releasing effects of ginsenoside Rg1 in hippocampus of beta-amyloid model rats
- Liu, Yang, Gao, Yan, Li, Ke-Xin, Xue, Wei
- Journal of Asian natural products research 2019 v.21 no.8 pp. 772-781
- Alzheimer disease, acetylcholine, amyloid, ginsenosides, hippocampus, liquid chromatography, microdialysis, models, pharmacokinetics, rats, tandem mass spectrometry
- This study aimed at investigating the pharmacokinetics (PK) and acetylcholine (Ach) releasing effects of ginsenoside Rg1 in hippocampus (HIP) of soluble oligomeric assemblies of amyloid beta (ADDLs) induced Alzheimer’s disease (AD) model rats. Extracellular fluid was collected by microdialysis technique. The concentrations of Rg1 and Ach in dialysates were detected by liquid chromatography–tandem mass spectrometry (LC–MS/MS) method. The results showed, after administration, Rg1 was soon detected in the HIP of model rats and extracellular Ach concentrations in the HIP were significantly increased.