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Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin

Qi-chen Yuan, Bi-yuan Zhan, Min Du, Rui Chang, Tian-ge Li, Xue-ying Mao
Journal of functional foods 2019 v.60 pp. 103435
anti-inflammatory activity, functional foods, glucose, glycogen, glycogen (starch) synthase, high fat diet, histology, hyperglycemia, hyperlipidemia, ingredients, liver, metabolism, mice, milk fat, mitogen-activated protein kinase, noninsulin-dependent diabetes mellitus, pancreas, skeletal muscle, streptozotocin, tau-protein kinase
Milk fat globule membrane (MFGM) was found to possess anti-cancer, anti-obesity and anti-inflammatory activities. The present study was carried out to evaluate the effects and possible underlying mechanisms of MFGM on type 2 diabetes (T2D) in mice. Results showed that 8-week MFGM supplementation had beneficial effects in ameliorating hyperglycemia and dyslipidemia in T2D mice induced with a high-fat diet and streptozotocin. MFGM also protected the liver and pancreas histological structures in T2D mice. Additionally, MFGM enhanced glycogen synthesis, which was associated with inhibition of glycogen synthase kinase 3 beta and activation of glycogen synthase. Furthermore, a mechanistic study illuminated that MFGM likely ameliorated glucose metabolism disorder by promoting the phosphatidylinositol 3-kinase/protein kinase B pathway while suppressing c-Jun N-terminal kinase signaling in liver and skeletal muscle. These findings suggest that MFGM may be useful as a potential functional food ingredient against diabetes.