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Catalase-mimetic gold nanoparticles inhibit the antagonistic action of Lactobacillus gasseri toward foodborne enteric pathogens in associative cultures

Author:
Zhu, Suqin, Zeng, Mingyong, Guo, Wei, Feng, Guangxin, Wu, Haohao
Source:
Journal of environmental science and health 2019 v.37 no.2 pp. 55-66
ISSN:
1532-4095
Subject:
Escherichia coli, Lactobacillus gasseri, Listeria monocytogenes, Salmonella Typhimurium, Staphylococcus aureus, antibacterial properties, citrates, colitis, dysbiosis, enteropathogens, hydrogen peroxide, intestines, mice, nanogold, polyvinylpyrrolidone, tannins
Abstract:
Gold nanoparticles (AuNPs) have been previously shown to induce gut dysbiosis during colitis in mice, but the underlying mechanism is not clear yet. Here, we evaluated the effects of AuNPs (5 nm diameter, coated with tannic acid, polyvinylpyrrolidone or citrate) on H₂O₂ accumulation and pathogen antagonization by an intestinal strain of Lactobacillus gasseri under aerobic cultural conditions. AuNPs (0.65 μg/mL) reduced over 50% of H₂O₂ accumulation by L. gasseri, and significantly inhibited the antagonistic action of L. gasseri on growth of four foodborne enteric pathogens, i.e. Salmonella enterica serovar Typhimurium, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus in associative cultures.
Agid:
6489010